The Callaway County Commission has adopted and set the following holiday schedule for 2022. The courthouse will be closed in observation of these days.
| New Year’s Day | Friday | December 31, 2021 |
| Martin Luther King, Jr. Day | Monday | January 17, 2022 |
| Lincoln’s Birthday | Friday | February 11, 2022 |
| Washington’s Birthday | Monday | February 21, 2022 |
| Truman Day | Monday | May 9, 2022 |
| Memorial Day | Monday | May 30, 2022 |
| Emancipation Day | Monday | June 20, 2022 *Pending* |
| Independence Day | Monday | July 4, 2022 |
| Labor Day | Monday | September 5, 2022 |
| Columbus Day | Monday | October 10, 2022 |
| Veterans Day | Friday | November 11, 2022 |
| Thanksgiving Day | Thurs/Fri | November 24 & 25, 2022 |
| Christmas Day | Monday | December 26, 2022 |
* Emancipation Day: Pending the State of Missouri’s decision.